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This is Scientific American 60-Second Science. I'm Christopher Intagliata. Got a minute?

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Some 70 million American adults have high blood pressure.

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Three quarters of them rely on medication to keep the condition in check.

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But you've got to remember to actually take the daily dose.

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Now researchers have devised a longer-lasting alternative: a vaccine to lower blood pressure…for rats, at least.

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Scientists jabbed hypertensive rats with three doses of the formulation.

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It's a DNA vaccine, containing DNA fragments from angiotensin II, a hormone that boosts blood pressure, as well as fragments from hepatitis B, to guarantee the immune system's attention.

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Cells suck up the vaccine's DNA, and start pumping out the proteins the DNA codes for.

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When the host's defenses gets a whiff of the proteins, it reacts.

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It really revs up against the hepatitis B fragments.

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And while it's at it, it starts taking out some angiotensin II as well.

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The result is a reduction in angiotensin II's usual blood pressure raising effects—similar to what blood pressure meds like Benicar do.

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Less angiotensin II means more relaxed blood vessels, and a drop in pressure.

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That effect lasted six months in the vaccinated rats, and lengthened their lifespan by eight weeks.

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Necropsies on the vaccinated rats revealed healthier heart tissue than normally found with high blood pressure, and no damage to their kidneys or livers.

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The results are in the journal Hypertension.

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Other blood pressure vaccines have been tried, unsuccessfully.

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But this novel DNA-based vaccine could induce a longer-lasting effect.

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And the hope of twice-yearly shots instead of daily pills.

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Thanks for the minute, for Scientific American 60-Second Science. I'm Christopher Intagliata.

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