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1 .This is Scientific American 60-Second Science. I'm Christopher Intagliata. Got a minute?
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2 .Some 70 million American adults have high blood pressure.
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3 .Three quarters of them rely on medication to keep the condition in check.
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4 .But you've got to remember to actually take the daily dose.
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5 .Now researchers have devised a longer-lasting alternative: a vaccine to lower blood pressure…for rats, at least.
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6 .Scientists jabbed hypertensive rats with three doses of the formulation.
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7 .It's a DNA vaccine, containing DNA fragments from angiotensin II, a hormone that boosts blood pressure, as well as fragments from hepatitis B, to guarantee the immune system's attention.
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8 .Cells suck up the vaccine's DNA, and start pumping out the proteins the DNA codes for.
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9 .When the host's defenses gets a whiff of the proteins, it reacts.
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10 .It really revs up against the hepatitis B fragments.
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11 .And while it's at it, it starts taking out some angiotensin II as well.
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12 .The result is a reduction in angiotensin II's usual blood pressure raising effects—similar to what blood pressure meds like Benicar do.
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13 .Less angiotensin II means more relaxed blood vessels, and a drop in pressure.
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14 .That effect lasted six months in the vaccinated rats, and lengthened their lifespan by eight weeks.
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15 .Necropsies on the vaccinated rats revealed healthier heart tissue than normally found with high blood pressure, and no damage to their kidneys or livers.
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16 .The results are in the journal Hypertension.
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17 .Other blood pressure vaccines have been tried, unsuccessfully.
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18 .But this novel DNA-based vaccine could induce a longer-lasting effect.
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19 .And the hope of twice-yearly shots instead of daily pills.
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20 .Thanks for the minute, for Scientific American 60-Second Science. I'm Christopher Intagliata.
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