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This is Scientific American's 60-Second Science. I'm Karen Hopkin. This'll just take a minute.

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Sick of feeling chilly?

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Well, there may be a solution.

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Because researchers have generated genetically engineered mice that can't feel the cold.

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Their work is in the Journal of Neuroscience.

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All mammals, us included, sense temperature and touch through nerve cells in the skin.

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On these nerve cells are different types of receptors that respond either to mechanical pressure in the case of touch, or to heat or cold.

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Researchers were able to stop the production of the receptors for cold in the mice, while leaving the receptors for the other sensations intact.

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They then put the cold-insensitive mice and normal mice in a box where the temperature of the floor ranged from a freezing 32 degrees Fahrenheit to a toasty 122.

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And they found that the normal mice avoided both extremes,

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while mice without cold receptors shied away from the hot plate but had no qualms about the chill.

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Of course, the researchers were not trying to create comfy cold mice.

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The real intent was to see if it's possible to stop just one skin sensation.

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The hope is to design drugs that can dull pain without leaving patients numb.

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And thus to provide not-cold comfort.

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Thanks for the minute, for Scientific American's 60-Second Science. I'm Karen Hopkin.

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