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1 .This is Scientific American's 60-Second Science. I'm Karen Hopkin. This'll just take a minute.
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2 .Sick of feeling chilly?
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3 .Well, there may be a solution.
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4 .Because researchers have generated genetically engineered mice that can't feel the cold.
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5 .Their work is in the Journal of Neuroscience.
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6 .All mammals, us included, sense temperature and touch through nerve cells in the skin.
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7 .On these nerve cells are different types of receptors that respond either to mechanical pressure in the case of touch, or to heat or cold.
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8 .Researchers were able to stop the production of the receptors for cold in the mice, while leaving the receptors for the other sensations intact.
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9 .They then put the cold-insensitive mice and normal mice in a box where the temperature of the floor ranged from a freezing 32 degrees Fahrenheit to a toasty 122.
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10 .And they found that the normal mice avoided both extremes,
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11 .while mice without cold receptors shied away from the hot plate but had no qualms about the chill.
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12 .Of course, the researchers were not trying to create comfy cold mice.
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13 .The real intent was to see if it's possible to stop just one skin sensation.
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14 .The hope is to design drugs that can dull pain without leaving patients numb.
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15 .And thus to provide not-cold comfort.
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16 .Thanks for the minute, for Scientific American's 60-Second Science. I'm Karen Hopkin.
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