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This is Scientific American's 60-Second Science. I'm Steve Mirsky. Got a minute?

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"We've discovered that vitamin C kills Mycobacterium tuberculosis cells."

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TB researcher William Jacobs, with the Albert Einstein College of Medicine in the Bronx.

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"And in fact it works not only on the multidrug-resistant strains, but the totally drug-resistant strains as well."

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Jacobs was studying whether the TB drug isoniazid was being inactivated by the presence of a particular amino acid, cysteine,

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which in chemical terms acts as a reducing agent, by donating electrons.

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"So we added this with the isoniazid expecting that we'd get resistance.

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And to our surprise it actually led to sterilization.

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This reducing agent actually induced free radicals."

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Free radicals are highly reactive chemical entities that can damage cells.

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"And it was the free radicals that were killing the TB.

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We decided to try another reducing agent, vitamin C.

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We saw that just like the other reducing agent, it in combination with isoniazid sterilized the culture.

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Even more surprisingly, was when we just had vitamin C alone, we discovered that vitamin C kills tuberculosis.

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"We've only been able to demonstrate this in a test tube,

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and we don't know if it will work in humans.

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But before this study, you wouldn't have even thought about trying in humans."

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Thanks for the minute, for Scientific American's 60-Second Science. I'm Steve Mirsky.

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