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1 .This is Scientific American's 60-Second Science. I'm Steve Mirsky. Got a minute?
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2 ."We've discovered that vitamin C kills Mycobacterium tuberculosis cells."
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3 .TB researcher William Jacobs, with the Albert Einstein College of Medicine in the Bronx.
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4 ."And in fact it works not only on the multidrug-resistant strains, but the totally drug-resistant strains as well."
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5 .Jacobs was studying whether the TB drug isoniazid was being inactivated by the presence of a particular amino acid, cysteine,
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6 .which in chemical terms acts as a reducing agent, by donating electrons.
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7 ."So we added this with the isoniazid expecting that we'd get resistance.
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8 .And to our surprise it actually led to sterilization.
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9 .This reducing agent actually induced free radicals."
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10 .Free radicals are highly reactive chemical entities that can damage cells.
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11 ."And it was the free radicals that were killing the TB.
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12 .We decided to try another reducing agent, vitamin C.
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13 .We saw that just like the other reducing agent, it in combination with isoniazid sterilized the culture.
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14 .Even more surprisingly, was when we just had vitamin C alone, we discovered that vitamin C kills tuberculosis.
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15 ."We've only been able to demonstrate this in a test tube,
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16 .and we don't know if it will work in humans.
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17 .But before this study, you wouldn't have even thought about trying in humans."
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18 .Thanks for the minute, for Scientific American's 60-Second Science. I'm Steve Mirsky.
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