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1 .This is Scientific American's 60-Second Science. I'm Karen Hopkin.This'll just take a minute.
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2 .It's one of marijuana's most well-known side effects: the ravenous desire for food commonly called the munchies.
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3 .But why does weed make chocolate, chips and, as the Harold and Kumar documentaries have shown, White Castle sliders so irresistible?
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4 .Finally, science may have an answer.
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5 .The urge to eat is controlled by complex circuits of neurons in the brain.
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6 .Some of these nerve cells make us feel hungry, driving us to eat.
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7 .Others cause us to feel sated, so we put down the Doritos bag and stop filling our faces.
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8 .To figure out how marijuana might hijack this system, researchers exposed mice to a chemical that mimics the effect of the active ingredient in cannabis, THC, by binding to the brain's THC receptors.
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9 .These doped-up rodents tend to keep noshing, even if they've already eaten their fill.
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10 .But what's going on in their little mouse brains?
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11 .Or paradoxically, the researchers found that the cannabinoid receptor turns on the neurons that normally make animals feel full.
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12 .But what happens next is different from usual.
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13 .When the "hey-I'm-full" neurons get triggered by the THC receptors, they wind up sending a "hey-I'm-still-hungry" signal that send us scrambling for the cupcakes.
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14 .(This is your brain on drugs.)
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15 .In addition to explaining 4 a.m.diner trips, the research, in the journal Nature, may be useful for addressing the medical condition of appetite loss. It commonly happen with cancer and depression for example.
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16 .Knowing these details of neuronal activity could lead to better treatments for those patients who could really benefit from a case of the munchies.
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17 .Thanks for the minute, for Scientific American's 60-Second Science. I'm Karen Hopkin.
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