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This is Scientific American 60-Second Science. I'm Cynthia Graber. Got a minute?
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If you need a new liver, doctors have about twelve hours to transport it from a donor.
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That ticking clock severely limits the ability of doctors to get organs to patients.
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Now researchers have demonstrated a method that kept rat livers viable up to four days.
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The scientists lowered the livers to below freezing temperatures, while flooding the tissue with antifreeze chemicals to prevent the formation of damaging ice crystals.
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But such cooling alone is not sufficient, due in part to the liver's wide variety of cell types and functions.
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So the researchers also used machine perfusion: as the livers were cooled they were flushed with solutions that kept them operational.
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They were perfused again as they were brought back to above-freezing temps.
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All the rats that were implanted with 3-day-old livers survived for three months.
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Nearly 60 percent of the rats with four-day-old livers survived.
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In contrast, no rats that received 3- and 4-day-old livers preserved by currently used methods survived.
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This work is an early step toward creating a system that could work in humans,
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which would dramatically improve the chances of getting organs to people who desperately need them.
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Thanks for the minute, for Scientific American 60-Second Science. I'm Cynthia Graber.
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显示原文 =This is Scientific American 60-Second Science. I'm Cynthia Graber. Got a minute?
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显示原文 =If you need a new liver, doctors have about twelve hours to transport it from a donor.
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3 / 14
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显示原文 =That ticking clock severely limits the ability of doctors to get organs to patients.
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4 / 14
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显示原文 =Now researchers have demonstrated a method that kept rat livers viable up to four days.
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5 / 14
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显示原文 =The scientists lowered the livers to below freezing temperatures, while flooding the tissue with antifreeze chemicals to prevent the formation of damaging ice crystals.
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6 / 14
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显示原文 =But such cooling alone is not sufficient, due in part to the liver's wide variety of cell types and functions.
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7 / 14
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显示原文 =So the researchers also used machine perfusion: as the livers were cooled they were flushed with solutions that kept them operational.
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8 / 14
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显示原文 =They were perfused again as they were brought back to above-freezing temps.
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9 / 14
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显示原文 =All the rats that were implanted with 3-day-old livers survived for three months.
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10 / 14
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显示原文 =Nearly 60 percent of the rats with four-day-old livers survived.
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11 / 14
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显示原文 =In contrast, no rats that received 3- and 4-day-old livers preserved by currently used methods survived.
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12 / 14
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显示原文 =This work is an early step toward creating a system that could work in humans,
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13 / 14
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显示原文 =which would dramatically improve the chances of getting organs to people who desperately need them.
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14 / 14
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显示原文 =Thanks for the minute, for Scientific American 60-Second Science. I'm Cynthia Graber.
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- 单句循环:关
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