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This is Scientific American 60-Second Health. I'm Dina Fine Maron. Got a minute?
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Living longer doesn't necessarily mean living better.
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That's the lesson from the tiny roundworm called C.elegans, long a workhorse in basic biology lab work.
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The research is in the Proceedings of the National Academy of Sciences.
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In the study, thousands of normal C.elegans competed against strains that live days or weeks longer than their brethren, because of factors like genetic mutations or very low-calorie diets.
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But a battery of tests to see how the all older worms moved or responded to stress revealed some hard truths:
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increased life span did not usually come with a prolonged period of health and strength.
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Indeed, the "good times" for each of the worms was roughly the same, regardless of their overall life span.
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In other words, the longer-living worms spent a greater proportion of their lives in a diminished state with less mobility and stress resistance.
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Aging worms are not aging humans.
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But if the findings do extend to people, then life-extension efforts, such as calorie restriction, may not shake out to a better old age, just more years of frailty.
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With associated healthcare cost increases and quality of life decreases.
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The researchers suggest that it's time to start thinking about what they call "healthspan" and maximizing "healthspan," rather than just tacking on years of poor quality.
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Thanks for the minute, for Scientific American 60-Second Health.I'm Dina Fine Maron.
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显示原文 =This is Scientific American 60-Second Health. I'm Dina Fine Maron. Got a minute?
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2 / 14
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显示原文 =Living longer doesn't necessarily mean living better.
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显示原文 =That's the lesson from the tiny roundworm called C.elegans, long a workhorse in basic biology lab work.
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4 / 14
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显示原文 =The research is in the Proceedings of the National Academy of Sciences.
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显示原文 =In the study, thousands of normal C.elegans competed against strains that live days or weeks longer than their brethren, because of factors like genetic mutations or very low-calorie diets.
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6 / 14
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显示原文 =But a battery of tests to see how the all older worms moved or responded to stress revealed some hard truths:
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7 / 14
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显示原文 =increased life span did not usually come with a prolonged period of health and strength.
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8 / 14
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显示原文 =Indeed, the "good times" for each of the worms was roughly the same, regardless of their overall life span.
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9 / 14
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显示原文 =In other words, the longer-living worms spent a greater proportion of their lives in a diminished state with less mobility and stress resistance.
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10 / 14
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显示原文 =Aging worms are not aging humans.
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11 / 14
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显示原文 =But if the findings do extend to people, then life-extension efforts, such as calorie restriction, may not shake out to a better old age, just more years of frailty.
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12 / 14
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显示原文 =With associated healthcare cost increases and quality of life decreases.
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13 / 14
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显示原文 =The researchers suggest that it's time to start thinking about what they call "healthspan" and maximizing "healthspan," rather than just tacking on years of poor quality.
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14 / 14
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显示原文 =Thanks for the minute, for Scientific American 60-Second Health.I'm Dina Fine Maron.
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- 单句循环：关
- 单句循环：×3
- 单句循环：×5
- 单句循环：∞