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1 .This is Scientific American 60-Second Science. I'm Christopher Intagliata. Got a minute?
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2 .The pain-relieving effects of drugs like ibuprofen are well known.
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3 .But ibuprofen and its relatives, known as nonsteroidal anti-inflammatory drugs, may someday have another use as antibiotics.
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4 .Researchers tested three anti-inflammatory drugs: bromfenac, used in eye drops, and carprofen and vedaprofen, both for treating conditions like arthritis in dogs.
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5 .The investigators found that all three drugs bind to something called the "DNA clamp" in bacteria.
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6 .That clamp is essential to repairing and replicating DNA.
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7 .By jamming it, the painkillers can actually kill live E. coli in a test tube, at least.
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8 .The findings appear in the journal Chemistry & Biology.
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9 .Study author Aaron Oakley, of Australia's University of Wollongong, says we still need clinical trials to tell if this trick holds true in humans.
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10 .But this study is a first step.
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11 ."I guess it alerts a lot of clinicians to the fact that some of the nonsteroidal anti-inflammatories that they're using may have this off-target effect."
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12 .And it gives drug developers like Oakley and his colleagues, a whole new way to attack antibiotic-resistant bacteria.
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13 .Thanks for the minute, for Scientific American 60-Second Science. I'm Christopher Intagliata.
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