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This is Scientific American 60-Second Science. I'm Christopher Intagliata. Got a minute?

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If you're serious about fitness, you know the importance of training your muscles and your brain.

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Without the right prep, you won't have the physical or mental endurance to finish, whether it's a 5k or an Ironman.

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But it turns out that it may be just as important to train your gut—or suffer inflammatory consequences.

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So says a study in the International Journal of Sports Medicine.

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Researchers sampled the blood of 17 runners before and after a 24-hour ultramarathon—where runners covered anywhere from 75 to 130 miles on foot.

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During the race, their guts got leaky, due to a lack of blood flow to the intestines, and the physical trauma from so many jarring miles.

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Gut bacteria escaped into the blood, where some released toxins.

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The runners' bodies then responded by launching an immune response, and inflammation set in.

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Some runners actually had blood profiles identical to those of patients admitted to the hospital with blood poisoning, or sepsis.

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But the most well-trained competitors avoided the problem.

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Their bodies launched a counterattack, unleashing anti-inflammatory compounds to tamp down their bodies' immune overreaction.

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The authors say just four hours of activity is extreme enough to kick off this chain of inflammation.

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Suggesting it's key to gradually build up to new personal bests, even if they're not ultra-worthy.

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As has long been said: slow and steady wins the race.

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Thanks for the minute, for Scientific American 60-Second Science. I'm Christopher Intagliata.

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1 / 16
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This is Scientific American 60-Second Science. I'm Christopher Intagliata. Got a minute?

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If you're serious about fitness, you know the importance of training your muscles and your brain.

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Without the right prep, you won't have the physical or mental endurance to finish, whether it's a 5k or an Ironman.

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But it turns out that it may be just as important to train your gut—or suffer inflammatory consequences.

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So says a study in the International Journal of Sports Medicine.

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Researchers sampled the blood of 17 runners before and after a 24-hour ultramarathon—where runners covered anywhere from 75 to 130 miles on foot.

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During the race, their guts got leaky, due to a lack of blood flow to the intestines, and the physical trauma from so many jarring miles.

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Gut bacteria escaped into the blood, where some released toxins.

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The runners' bodies then responded by launching an immune response, and inflammation set in.

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Some runners actually had blood profiles identical to those of patients admitted to the hospital with blood poisoning, or sepsis.

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But the most well-trained competitors avoided the problem.

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Their bodies launched a counterattack, unleashing anti-inflammatory compounds to tamp down their bodies' immune overreaction.

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The authors say just four hours of activity is extreme enough to kick off this chain of inflammation.

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Suggesting it's key to gradually build up to new personal bests, even if they're not ultra-worthy.

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As has long been said: slow and steady wins the race.

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Thanks for the minute, for Scientific American 60-Second Science. I'm Christopher Intagliata.

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